“Coffee cures Alzheimer’s.” This sounds like great news for me personally, given that generally I drink enough coffee per day to wake up the population of a small town.

Am I drinking the right amount, though? How much do you need to drink to avoid – nay, cure – the dread disease?

The Independent claims that a modest cup a day will do it.

A coffee a day ensures the memory will stay

The BBC has a more demanding coffee-drinking schedule. And it’s a lot more tentative about the good it will do.

Coffee ‘may reverse Alzheimer’s’
A possible treatment for dementia?
Drinking five cups of coffee a day could reverse memory problems seen in Alzheimer’s disease, US scientists say.

Wait, a mere two cups of coffee might do it.

The mice were given the equivalent of five 8 oz (227 grams) cups of coffee a day – about 500 milligrams of caffeine.
The researchers say this is the same as is found in two cups of “specialty” coffees such as lattes or cappuccinos from coffee shops, 14 cups of tea, or 20 soft drinks.

It may be too pedantic to point out that a latte or cappuccino are defined by the milk, rather than by the caffeine content. I take it they are using these as shorthand for “real” rather than instant coffee. Ground coffee or espresso may just be too unfashionable to mention.

The Daily Express actually led with this news item covering its front page, in some print editions. It thinks two coffees is the magic quantity.

TWO CUPS OF COFFEE A DAY STOPS ALZHEIMER’S
DRINKING two cups of coffee a day reverses the effects of Alzheimer’s, ground-breaking research has revealed.
Scientists say powerful evidence shows caffeine not only helps to stave off the disease but can even treat it, as it helps to sharpen the memory.

This news item is a mite less groundbreaking than it appears. There was a similar story last year. The protective volume of coffee was one cup a day.

“This is the best evidence yet that caffeine equivalent to one cup of coffee a day can help protect the brain against cholesterol.

In that experiment, it was rabbits that got the caffeine. The poor buggers were killed, of course, but at least they they were just regular rabbits, as far as I can make out.*

Not so the mice. They were bred to have symptoms of Alzheimers. I am sure you will correct my neuroscience idiocy but – is that really the same as human beings having Alzheimers? Or so close to the same as dammit?

(I have serious doubts about the applicability of this research to humans. Serious enough to say that – in the astronomically unlikely event that I were ever on a university ethics committee – I’d have said to these experimenters “Not a chance. You haven’t justified doing the Frankenstein thing of breeding creatures to be sick, in this case. First try some epidemiological studies of people.”)

The interesting thing is that the research report itself doesn’t even claim that coffee cures Alzheimers.

Researchers in the US have shown that caffeine can boost memory in mice with Alzheimer’s symptoms.
At the moment it is not clear whether caffeine can have the same effect in people. Researchers are now carrying out trials to see if caffeine can be beneficial for people with Alzheimer’s.(from the Alzheimers Research Trust website)

However, a casual scan of a few news items would leave you thinking that you only need to force a few doppio espressos down the throats of your formerly caffeine-free older relatives and they could emerge brighteyed from dementia.

(* Another paper in the same journal reckoned that

Acetaminophen inhibits neuronal inflammation and protects neurons from oxidative stress

I think that’s paracetemol to us. I’ll start swallowing two with my morning latte.)